Key Insights on Biohacking

First-order thinking means solving root causes with technology rather than either-or solutions, as demonstrated in Zappos distribution flow optimization

• Harvey and Cursor are reportedly building hybrid AI stacks using Chinese open-source models like GLM or KIMI alongside frontier US models as a cost-optimization strategy.
• Vertical integration eliminates up to 30 layers of subcontractors that create calcified interfaces and prevent system-level optimization
• Ketones serve as alternate brain fuel, with exogenous ketone supplements improving Alzheimer's symptoms within 20 minutes in some patients
• Sleep optimization is comprehensive - fixing one piece won't make the whole system function properly
• Cold exposure for 1-3 minutes paradoxically increases core body temperature, enhancing morning wakefulness through thermostat response
• Sleep supplements stack: 145mg magnesium threonate, 50mg apigenin, 100-400mg theanine taken 30-60 minutes before bed
• Plant-based diets can build equal muscle but require careful planning, isolated protein supplements, or free leucine to match animal protein quality.

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