Christian Angermayer, a biotech investor and advocate of human enhancement, joins the podcast to discuss his 'Next Human Agenda' - using technology and science to maximize human potential. Angermayer has founded multiple companies in psychedelics, longevity, and sports enhancement, including the controversial Enhanced Games.

The conversation explores Angermayer's philosophy of human optimization through FDA-approved substances, contrasting with the Pope's recent encyclical criticizing transhumanism. Topics range from the Enhanced Games' inaugural event in Las Vegas to the therapeutic potential of psychedelics, with Angermayer sharing his personal regimen including testosterone replacement therapy and GLP-1s.

The discussion delves into spiritual territory as Angermayer describes his psychedelic experiences and religious beliefs, referencing The Bible and The Quran as texts that reveal psychedelic influences when read with that perspective. The conversation concludes with a theological debate about enhancement versus acceptance of human limitations.

Enhanced Games: Redefining Athletic Competition

The Enhanced Games allows any FDA-approved substance while prohibiting non-approved drugs, using medical supervision rather than WADA's arbitrary restrictions.

"The real reason why the IOC hates us is not the doping... they treat the athletes like props, like tools" - Christian, criticizing unpaid Olympic athletes.

The inaugural games reached over 1 billion people with swimmer Christian Kolomeyev breaking a world record using performance enhancers.

Three categories of athletes competed: natural athletes, older athletes proving enhancement can reverse aging, and prime athletes like Kolomeyev demonstrating peak enhancement.

The Ozempic Revolution and Enhancement Markets

GLP-1 drugs like Ozempic generated more revenue than all AI companies combined, with over 50% of users taking them off-label for weight management.

"Once you take Ozempic and you lose like 15%, 20% of your weight, then you're like, well, fuck, I want that" - Christian on the transformative power of medical enhancement.

Angermayer predicts the pharmaceutical industry will shift toward enhancement drugs with larger addressable markets beyond just treating diseases.

His biotech company develops AMPK activator drugs that simultaneously build muscle and reduce weight with minimal exercise required.

Personal Enhancement Regimen and Philosophy

Angermayer's regimen includes testosterone replacement therapy since his 30s, GLP-1s for stress eating, DHEA, pregnenolone, and Quvivic for sleep enhancement.

"I can tell you with testosterone, like, it makes you feel like more than 10 years younger as a man, full stop" - Christian on TRT benefits.

He emphasizes covering five health basics first: sleep, social relations, avoiding recreational drugs (especially alcohol), exercise, and Mediterranean diet.

Blood cancer screening every three months represents his approach to preventive medicine and early detection.

Psychedelics: From Therapy to Spiritual Experience

Companies Atai and Compass raised over $1.5 billion for psychedelic drug development, with psilocybin entering phase 3 trials for treatment-resistant depression.

"5-MeO-DMT... was maybe the best dataset in neuroscience since like 30 years" - Christian on recent clinical trial results.

Angermayer takes psilocybin 1-2 times yearly with a therapist in countries where legal, describing encounters with God and spiritual revelations.

He believes psychedelics should only be used with clinicians due to their intensity and potential for uncovering trauma.

Religious Perspectives and Spiritual Enhancement

"Most religions are built on psychedelics" - Christian claims, citing his study of The Bible and The Quran after psychedelic experiences.

Reading The Bible post-psychedelics reveals passages about God's indescribable nature and the prohibition against making images of the divine.

Angermayer funded studies showing psychedelics can reduce dehumanization in conflicts, including sessions with Palestinians and Israelis together.

He argues the Catholic Church traded away mystical experience for organizational power, leaving people without direct spiritual connection.

Theological Debate: Enhancement vs. Acceptance

The host challenges whether human enhancement conflicts with Christian acceptance of suffering and embodied limitations as spiritually necessary.

"You have a responsibility... for the kids you put in this world to be there in a healthy state for them" - Christian defending enhancement as moral obligation.

Angermayer argues human curiosity and innovation represent the divine spark, making scientific enhancement inherently good rather than vain.

He contends that happiness and health are prerequisites for serving others, rejecting the notion that enhancement promotes narcissism.