Key ideas from Dominic D'agostino

• Tim achieved complete remission of Lyme disease cognitive symptoms within 3-4 days using strict ketosis, likely due to starving glycolytic spirochetes
• Dom warns that 1,3-butanediol-based ketone supplements can cause liver toxicity, dependency, and withdrawal symptoms with chronic use
• Optimal therapeutic ketosis range is 1-2 millimolar, with glucose ketone index (GKI) of 1-4 being the target for health benefits
• High insulin sensitivity from intermittent fasting can lead to increased ketone utilization, causing falsely low blood ketone readings
• MCT oil should be capped at 40ml daily (20ml twice) to avoid liver fat accumulation and toxicity
• One week per month of aggressive ketosis may provide lasting metabolic benefits through 'metabolic memory' effects
• Ketogenic diet elevates GABA and lowers glutamate, creating brain-stabilizing effects useful for psychiatric and neurological conditions
• Continuous glucose monitors can help delay Alzheimer's onset by providing awareness of blood sugar responses to foods